Many studies have explored the pathology of systemic lupus erythematosus sle, an autoimmune rheumatic disorder with a striking female predominance. New acr, eular criteria distinguish lupus from imitators. Disease activity varies over time and, at the onset, symptoms are very general and. Systemic lupus erythematosus is a disease that continues to evolve over time. The 2012 revised slicc criteria for classification of. Discoid rash raised erythematous patches with keratotic scaling, follicular plugging, and atrophic scarring 3.
Objective to develop new classification criteria for systemic lupus erythematosus sle jointly supported by the european league against rheumatism eular and the. Indeed, it is the diversity of presentation, accumulation of manifestations over time, and undulating disease course that challenge the most astute of clinicians. The most recent addendum to the classification criteria for sle dates from 2012, when the systemic lupus international collaborating clinics slicc group published a revision and validation of the acr criteria 5. Systemic lupus erythematosus is a systemic autoimmune disease with a worldwide distribution. Systemic lupus erythematosus sle is a chronic, multisystem autoimmune disease characterized by disorder of the generation of autoantibodies to components of cell nucleus, and the exact. With rare exception, the unifying laboratory abnormality is. The recent attempts to create modern criteria for the classification of sle have aimed at being more sensitive, clinically relevant and meaningful than the older american college of rheumatology acr classification criteria. If a patient meets at least four criteria, lupus can be diagnosed with 95% specificity and 85% sensitivity. Pathogenesis 20 and clinical features 1 introduction. In 2012, the systemic lupus international collaborating clinics slicc network presented a set of criteria based on almost 1400 patient scenarios, including a derivation and a validation of the new criteria as well as of the 1997 acr classification.
Researchers from around the world contributed to the development of classification criteria for systemic lupus erythematosus sle designed to distinguish the. Thus, a patient who presents with skin and joint disease remains at risk for renal disease even after having lupus. All patients with lupus should receive education, counseling, and support. Systemic lupus erythematosus, the most common form of lupus, is a chronic autoimmune disease that can cause severe fatigue and joint pain. Although both men and women of all age groups can be affected, women outnumber men almost 10 fold and.
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